Anti-Inflammatory Compounds from Atractylodes macrocephala
نویسندگان
چکیده
منابع مشابه
Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz.
Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I, atractylenolide II and atractylenolide III had inhibition ratios of 94.56 ± 0.70%, 90.93 ± 1.41% and 86.31 ± 8.46%, respectively, at a concentration of 10...
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Atractylenolide I (ATL-1) is the major sesquiterpenoid of Atractylodes macrocephala. This study was designed to investigate whether ATL-1 induced apoptosis in A549 and HCC827 cells in vitro and in vivo. In our results, ATL-1 significantly decreased the percentage of in vitro viability, in a dose-dependent manner. In addition, DAPI staining and flow cytometry tests demonstrated the induction of ...
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Rhizoma Atractylodes macrocephala (AM) has been used in Traditional Chinese Medicine (TCM) for about 2,000 years. In the study, we firstly determined the antioxidant levels of five AM extracts by •OH-scavenging, •O2−-scavenging, Fe2+-chelating, Cu2+-chelating, DPPH·-scavenging, and ABTS+·-scavenging assays. After measurement of the chemical contents in five AM extracts, we quantitatively analyz...
متن کاملPharmacokinetics of atractylenolide I from Atractylodes macrocephala Koidz in rats by RP-HPLC
Aim To establish an RP-HPLC method for the analysis of pharmacokinetics of atractylenolide I in rats. Methods The biological samples were extracted with ethyl acetate. The chromatographic conditions were as follows: An ODS column (4.6 × 150 mm, I.D, 5 μm) was used. The mobile phase was acetonitrile/water (55:45) with a flow rate of 1.0 mL·min under the room temperature, and the detection wavele...
متن کاملInduction of apoptosis and differentiation by atractylenolide-1 isolated from Atractylodes macrocephala in human leukemia cells.
Atractylodes macrocephula Koidz (A. macrocephula, also known as Baizhu) is an important ingredient in several traditional Chinese herb complexes for the treatment of abdominal pain and gastroenterology diseases for thousands of years. We previously demonstrated the induction of ROS-mediated apoptosis by methanol extract of A. macrocephula in human leukemia cells. After purification and assessme...
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ژورنال
عنوان ژورنال: Molecules
سال: 2019
ISSN: 1420-3049
DOI: 10.3390/molecules24101859